淡江大學數學系演講公告
主 講 人：劉  力  瑜    教授
        國立台灣大學 農藝學系暨研究所生物統計組
講   題： Statistical identification of gene association by CID in application of constructing gene regulatory network
日    期：99年5月25日（星期二）
時    間：下午2:30 –3:20
地    點：數學系(科學館S433室)
摘    要：
A variety of high-throughput techniques are now available for constructing 
comprehensive gene regulatory networks in systems biology. In this study, we 
report a new statistical approach for facilitating in silico inference of regulatory 
network structure. The new measure of association, coefficient of intrinsic 
dependence (CID), is model-free and can be applied to both continuous and 
categorical distributions. We apply CID to analyze the regulatory relationships 
between transcription factors (TFs) (X) and their downstream genes (Y) based 
on microarray expression data. A two-layer transcriptional regulatory network 
was established to exemplify the usage of CID, in combination with GPCC, in 
deciphering gene networks based on gene expression profiles from breast 
cancer clinical arrays.


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